Embryonic Stem Cell-Derived Cardiac Myocytes Are Not Ready for Human Trials

被引：49

作者：

Anderson, Mark E. ^{[1
,2
]}

Goldhaber, Joshua ^{[3
]}

Houser, Steven R. ^{[4
,5
]}

Puceat, Michel ^{[6
]}

Sussman, Mark A. ^{[7
]}

机构：

[1] Univ Iowa, Dept Internal Med, Cardiovasc Res Ctr, Carver Coll Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Mol Physiol & Biophys, Cardiovasc Res Ctr, Carver Coll Med, Iowa City, IA USA

[3] Cedars Sinai Heart Inst, Los Angeles, CA USA

[4] Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19122 USA

[5] Temple Univ, Cardiovasc Res Ctr, Sch Med, Philadelphia, PA 19122 USA

[6] Univ Aix Marseille, Team Physiopathol Cardiac Dev, Fac Med La Timone, INSERM,UMR 910, Marseille, France

[7] San Diego State Univ, Dept Biol, Integrated Regenerat Res Inst, San Diego, CA 92182 USA

来源：

CIRCULATION RESEARCH | 2014年 / 115卷 / 03期

关键词：

IN-VIVO; CARDIOMYOCYTES; HEARTS; DIFFERENTIATION; TRANSPLANTATION; EXPRESSION; SURVIVAL; CULTURE;

D O I：

10.1161/CIRCRESAHA.114.304616

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recently, a preclinical report assessed the efficacy, safety, and feasibility of using human embryonic stem cells to regenerate infarcted myocardium in a nonhuman primate model. This commentary evaluates that study by pointing out key weaknesses, offering an alternative perspective, and summarizing major unresolved issues. Our conclusion is that significant challenges remain before human embryonic stem cells are ready for use in clinical trials. © 2014 American Heart Association, Inc.

引用

页码：335 / 338

页数：4

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