Nickel-catalyzed cross-coupling of aryl Grignard reagents with aromatic alkyl ethers: An efficient synthesis of unsymmetrical biaryls

被引：241

作者：

Dankwardt, JW ^{[1
]}

机构：

[1] DSM Pharmaceut Chem, Greenville, NC 27834 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 18期

关键词：

anisole; biaryls; C-C coupling; nickel; phosphane ligands;

D O I：

10.1002/anie.200453765

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New substrates for biaryl synthesis: aromatic ethers undergo nickel-catalyzed cross-coupling with aryl Grignard reagents to give unsymmetrical biaryls in excellent yields (see scheme). Both the nature of the nickel catalyst and the choice of solvent are crucial for reaching high levels of conversion.

引用

页码：2428 / 2432

页数：5

共 24 条

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