Cancer of pancreas

被引:18
作者
de Braud, F [1 ]
Cascinu, S
Gatta, G
机构
[1] START Project, Milan, Italy
[2] European Inst Oncol, Milan, Italy
[3] Univ Politecn Marche, Div Med Oncol, Ancona, Italy
[4] Ist Nazl Studio & Cura Tumori, Milan, Italy
关键词
jaundice; neoplasm; carcinoma;
D O I
10.1016/S1040-8428(03)00156-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer of the pancreas is the tenth most frequent cancer in Europe, accounting for some 3% of cancer in both sex. Smoking has been clearly established as a major risk factor affecting the carcinogenesis of pancreatic carcinoma. Diet has also been associated with pancreatic cancer, although no conclusive data are yet available. Different genetic alterations have been observed in pancreatic neoplasms. Typical symptoms of pancreatic cancer are: jaundice, abdominal pain and weight loss. The prognosis of pancreatic carcinoma depends mainly on radical surgery and the presence of negative resection margins, as well as on the biological tumour stage, which also influences the treatment strategy. The treatment of pancreatic cancer is undertaken with two aims. Radical surgery is indicated for patients with early stage of disease, mainly stage 1 and partially II. In all other cases, the aim of treatment is the palliation of different very distressing symptoms related to this neoplasm. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:147 / 155
页数:9
相关论文
共 42 条
[1]   MOST HUMAN CARCINOMAS OF THE EXOCRINE PANCREAS CONTAIN MUTANT C-K-RAS GENES [J].
ALMOGUERA, C ;
SHIBATA, D ;
FORRESTER, K ;
MARTIN, J ;
ARNHEIM, N ;
PERUCHO, M .
CELL, 1988, 53 (04) :549-554
[2]   RANDOMIZED TRIAL OF ENDOSCOPIC ENDOPROSTHESIS VERSUS OPERATIVE BYPASS IN MALIGNANT OBSTRUCTIVE-JAUNDICE [J].
ANDERSEN, JR ;
SORENSEN, SM ;
KRUSE, A ;
ROKKJAER, M ;
MATZEN, P .
GUT, 1989, 30 (08) :1132-1135
[3]  
[Anonymous], 1987, Cancer, V59, P2006
[4]  
[Anonymous], 2001, Cancer incidence, mortality and prevalence worldwide. 1
[5]   Ten-year experience with 733 pancreatic resections - Changing indications, older patients, and decreasing length of hospitalization [J].
Balcom, JH ;
Rattner, DW ;
Warshaw, AL ;
Chang, Y ;
Fernandez-del Castillo, C .
ARCHIVES OF SURGERY, 2001, 136 (04) :391-397
[6]   Current concepts: Expandable metal stents for the treatment of cancerous obstruction of the gastrointestinal tract. [J].
Baron, TH .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (22) :1681-1687
[7]   Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy [J].
Birkmeyer, JD ;
Finlayson, SRG ;
Tosteson, ANA ;
Sharp, SM ;
Warshaw, AL ;
Fisher, ES .
SURGERY, 1999, 125 (03) :250-256
[8]  
BORNMAN PC, 1986, LANCET, V1, P69
[9]   Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial [J].
Burris, HA ;
Moore, MJ ;
Andersen, J ;
Green, MR ;
Rothenberg, ML ;
Madiano, MR ;
Cripps, MC ;
Portenoy, RK ;
Storniolo, AM ;
Tarassoff, P ;
Nelson, R ;
Dorr, FA ;
Stephens, CD ;
VanHoff, DD .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2403-2413
[10]  
CRUCITTI F, 1995, INT J PANCREATOL, V17, P37