Non-protein coding RNA biomarkers and differential expression in cancers: a review

被引：52

作者：

Mallardo, Massimo ^{[1
]}

Poltronieri, Palmiro ^{[2
]}

D'Urso, Oscar Fernando ^{[3
]}

机构：

[1] Univ Naples Federico II, Dept Biochem & Med Biotechnol, Naples, Italy

[2] Ecotekne, Inst Sci Food Prod, Natl Res Council, Lecce, Italy

[3] Ecotekne, Biotecgen, Lecce, Italy

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2008年 / 27卷 / 1期

关键词：

D O I：

10.1186/1756-9966-27-19

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In these years a huge number of human transcripts has been found that do not code for proteins, named non-protein coding RNAs. In most cases, small (miRNAs, snoRNAs) and long RNAs (antisense RNA, dsRNA, and long RNA species) have many roles, functioning as regulators of other mRNAs, at transcriptional and post-transcriptional level, and controlling protein ubiquitination and degradation. Various species of npcRNAs have been found differentially expressed in different types of cancer. This review discusses the published data and new results on the expression of a subset of npcRNAs. Conclusion: These results underscore the complexity of the RNA world and provide further evidence on the involvement of functional RNAs in cancer cell growth control.

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页数：12

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