Total synthesis of zincophorin and its methyl ester

被引:49
作者
Defosseux, M [1 ]
Blanchard, N [1 ]
Meyer, C [1 ]
Cossy, J [1 ]
机构
[1] Ecole Super Phys & Chim Ind Ville Paris, Chim Organ Lab, CNRS, F-75231 Paris 05, France
关键词
D O I
10.1021/jo0496042
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A total synthesis of the naturally occurring ionophore zincophorin has been realized. The route features an intramolecular oxymercuration of a cyclopropanemethanol and a Carroll-Claisen rearrangement for the respective elaboration of the C1-C12 and C13-C25 subunits, which have been assembled by using a highly diastereoselective titanium-mediated aldol condensation.
引用
收藏
页码:4626 / 4647
页数:22
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