Sequencing analysis of prion genes from red deer and camel

被引：17

作者：

Kaluz, S ^{[1
]}

Kaluzova, M ^{[1
]}

Flint, APF ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,LOUGHBOROUGH LE12 5RD,LEICS,ENGLAND

来源：

GENE | 1997年 / 199卷 / 1-2期

关键词：

polymerase chain reaction; ruminants; spongiform encephalopathy; ungulates;

D O I：

10.1016/S0378-1119(97)00382-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An abnormal isoform of the prion protein (PrP) appears to be the agent responsible for transmissible spongiform encephalopathies (TSE). The normal isoform of PrP is host-encoded and expressed in the central nervous system. The recent bovine spongiform encephalopathy (BSE) epidemic in the UK and the incidence of prion-related diseases in other animals could indicate that ruminants are highly susceptible to infection via ingestion of prion-contaminated food. Sequence analysis of PrP gene open reading frames from red deer and camel was carried out to investigate sequence variability of these genes among ruminants. (C) 1997 Elsevier Science B.V.

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收藏

页码：283 / 286

页数：4

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