A diversity-oriented strategy for the construction of tetrasubstituted pyrroles via coupled domino processes

被引:113
作者
Tejedor, D
González-Cruz, D
García-Tellado, F
Marrero-Tellado, JJ
Rodríguez, ML
机构
[1] CSIC, InsproInst Prod Nat & Agrobiol, E-38206 Tenerife, Canary Islands, Spain
[2] Univ La Laguna, Inst Canario Invest Canc, E-38206 Tenerife, Canary Islands, Spain
[3] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, E-38206 Tenerife, Canary Islands, Spain
关键词
D O I
10.1021/ja047396p
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new microwave-assisted rearrangement of 1,3-oxazolidines scaffolds is the basis for a new, metal-free, direct, and modular construction of tetrasubstituted pyrroles from terminal-conjugated alkynes, aldehydes, and primary amines. This new reaction manifold entails two linked domino processes in a one-pot manner with both atom- and bond-efficiency and under very simple and environment-friendly experimental conditions. Copyright © 2004 American Chemical Society.
引用
收藏
页码:8390 / 8391
页数:2
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