The GABA nervous system in C. elegans

被引：119

作者：

Schuske, K ^{[1
]}

Beg, AA ^{[1
]}

Jorgensen, EM ^{[1
]}

机构：

[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 07期

关键词：

D O I：

10.1016/j.tins.2004.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding five different proteins: the biosynthetic enzyme for GABA, the vesicular GABA transporter, a transcription factor that determines GABA neuron identity, a classic inhibitory GABA receptor and a novel excitatory GABA receptor. This review discusses the strategy employed to identify these genes as well as the conclusions about GABA transmission derived from study of the mutant phenotypes.

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页码：407 / 414

页数：8

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