Molecular cloning, mRNA expression and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2)

被引：61

作者：

Komatsu, T

Suzuki, Y

Imai, J

Sugano, S

Hida, M

Tanigami, A

Muroi, S

Yamada, Y

Hanaoka, K

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Struct,Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Dept Anesthesiol, Minato Ku, Tokyo 1088639, Japan

[3] Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Tokushima 7710192, Japan

来源：

DNA SEQUENCE | 2002年 / 13卷 / 04期

关键词：

angiotensin converting enzyme; zinc metallopeptidase; chromosome X; RT-PCR;

D O I：

10.1080/1042517021000021608

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We isolated two mouse cDNA clones which show significant similarities with human angiotensin-converting enzyme-related carboxypeptidase (ACE2). The cDNAs were 2746 and 1995 bp in length and seemed to arise from the same gene by alternative splicing. The longer cDNA encoded a 798-amino acid protein containing the sequence motif conserved among zinc metallopeptidases. Mouse ACE2 showed 83% identity with human ACE2. Northern blot analysis revealed that 2.8- and 2.0-kb transcripts were expressed mainly in the kidney and the lungs. The mouse ACE2 gene was mapped to chromosome x 70.5 cM.

引用

页码：217 / 220

页数：4

共 12 条

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