Identification of an epitope common to genogroup 1 "Norwalk-like viruses"

被引：42

作者：

Hale, AD

Tanaka, TN

Kitamoto, N

Ciarlet, M

Jiang, X

Takeda, N

Brown, DWG

Estes, MK

机构：

[1] Baylor Coll Med, Div Mol Virol, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Eastern Virginia Med Sch, Ctr Pediat Res, Norfolk, VA 23510 USA

[3] Cent Publ Hlth Lab, Enter & Resp Virus Lab, London NW9 5HT, England

[4] Wakayama Med Coll, Dept Microbiol, Wakayama 640, Japan

[5] Himeji Inst Technol, Sch Humanities Environm Policy & Technol, Himeji, Hyogo 67122, Japan

[6] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2000年 / 38卷 / 04期

关键词：

D O I：

10.1128/JCM.38.4.1656-1660.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A panel of 10 monoclonal antibodies (MAbs) to recombinant Norwalk virus (NV) capsid protein were tested in competition enzyme-linked immunosorbent assays. Patterns of competition indicated that these MAbs recognize six to eight epitopes covering five nonoverlapping regions of the capsid protein. A single epitope, recognized by NV MAbs NV3901, NV3912, and NV2461 was found to occur in the majority of genogroup 1 (G1) but not genogroup 2 (G2) "Norwalk-like viruses" (NLVs). This observation supports the subdivision of human NLVs into two genogroups and provides an assay for the rapid identification of G1 NLVs in fecal specimens.

引用

页码：1656 / 1660

页数：5

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