Molecular structure of P2X receptors

被引:35
作者
Egan, TM [1 ]
Cox, JA [1 ]
Voigt, MM [1 ]
机构
[1] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA
关键词
D O I
10.2174/1568026043451005
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
P2X receptors are ligand-gated ion channels that transduce many of the physiological effects of extracellular ATP. There has been a dramatic increase in awareness of these receptors over the past 5 or so years, in great part due to their molecular cloning and characterization. The availability of cDNA clones for the various subunits has led to rapid progress in identifying their tissue-specific expression, resulting in new ideas concerning the functional roles these receptors might play in physiological and pathophysiological processes. In addition, molecular approaches have yielded much information regarding the structure and function of the receptor proteins themeslves. In this review we seek to review recent findings concerning the molecular determinants of receptor-channel function, with particular focus on ligand binding and gating, ion selectivity, and subunit assembly.
引用
收藏
页码:821 / 829
页数:9
相关论文
共 80 条
[1]   Zinc and copper modulate differentially the P2X4 receptor [J].
Acuña-Castillo, C ;
Morales, B ;
Huidobro-Toro, JP .
JOURNAL OF NEUROCHEMISTRY, 2000, 74 (04) :1529-1537
[2]   ATP-activated cationic and anionic conductances in cultured rat hippocampal neurons [J].
Balachandran, C ;
Bennett, MR .
NEUROSCIENCE LETTERS, 1996, 204 (1-2) :73-76
[3]   RECEPTOR CLASSES AND THE TRANSMITTER-GATED ION CHANNELS [J].
BARNARD, EA .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :368-374
[4]   PHARMACOLOGY AND ELECTROPHYSIOLOGY OF ATP-ACTIVATED ION CHANNELS [J].
BEAN, BP .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (03) :87-90
[5]   A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X2 ATP-gated channels [J].
Boué-Grabot, É ;
Archambault, V ;
Séguéla, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10190-10195
[6]   NEW STRUCTURAL MOTIF FOR LIGAND-GATED ION CHANNELS DEFINED BY AN IONOTROPIC ATP RECEPTOR [J].
BRAKE, AJ ;
WAGENBACH, MJ ;
JULIUS, D .
NATURE, 1994, 371 (6497) :519-523
[7]   Desensitization of the P2X(2) receptor controlled by alternative splicing [J].
Brandle, U ;
Spielmanns, P ;
Osteroth, R ;
Sim, J ;
Surprenant, A ;
Buell, G ;
Ruppersberg, JP ;
Plinkert, PK ;
Zenner, HP ;
Glowatzki, E .
FEBS LETTERS, 1997, 404 (2-3) :294-298
[8]   An antagonist-insensitive P-2X receptor expressed in epithelia and brain [J].
Buell, G ;
Lewis, C ;
Collo, G ;
North, RA ;
Surprenant, A .
EMBO JOURNAL, 1996, 15 (01) :55-62
[9]   EPITHELIAL SODIUM-CHANNEL RELATED TO PROTEINS INVOLVED IN NEURODEGENERATION [J].
CANESSA, CM ;
HORISBERGER, JD ;
ROSSIER, BC .
NATURE, 1993, 361 (6411) :467-470
[10]   Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity [J].
Clarke, CE ;
Benham, CD ;
Bridges, A ;
George, AR ;
Meadows, HJ .
JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 (03) :697-703