Regulation of the ROMK channel: interaction of the ROMK with associate proteins

被引：34

作者：

Wang, WH ^{[1
]}

机构：

[1] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 1999年 / 277卷 / 06期

关键词：

adenosine 5 '-triphosphate-sensitive potassium channel; cystic fibrosis transmembrane conductance regulator; protein kinase A; A kinase anchoring protein;

D O I：

10.1152/ajprenal.1999.277.6.F826

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The ROMK channel plays an important role in K recycling in the thick ascending limb (TAL) and K secretion in the cortical collecting duct (CCD). A large body of evidence indicates that the ROMK channel is a key component of the native K secretory channel identified in the apical membrane of the TAL and the CCD. Although the ROMK channel shares several key regulatory mechanisms with the native K secretory channel in a variety of respects, differences in the channel modulatory mechanism are clearly present between the ROMK channel and the native K secretory channel. Therefore, it is possible that additional associate proteins are required to interact with the ROMK channel to assemble the native K secretory channel. This notion is supported by recent reports showing that cystic fibrosis transmembrane conductance regulator (CFTR) and A kinase anchoring proteins (AKAP) interact with the ROMK channels to restore the response to ATP sensitivity and protein kinase A stimulation. This review is an attempt to summarize the up-to-date progress regarding the interaction between the ROMK channel and the associate proteins in forming the native K secretory-channel.

引用

页码：F826 / F831

页数：6

共 71 条

[1] Toward understanding the assembly and structure of KATP channels [J].

Aguilar-Bryan, L ;

Clement, JP ;

Gonzalez, G ;

Kunjilwar, K ;

Babenko, A ;

Bryan, J .

PHYSIOLOGICAL REVIEWS, 1998, 78 (01) :227-245

[2] CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION [J].

AGUILARBRYAN, L ;

NICHOLS, CG ;

WECHSLER, SW ;

CLEMENT, JP ;

BOYD, AE ;

GONZALEZ, G ;

HERRERASOSA, H ;

NGUY, K ;

BRYAN, J ;

NELSON, DA .

SCIENCE, 1995, 268 (5209) :423-426

[3] The A kinase anchoring protein is required for mediating the effect of protein kinase A on ROMK1 channels [J].

Ali, S ;

Chen, X ;

Lu, M ;

Xu, JZ ;

Lerea, KM ;

Hebert, SC ;

Wang, WH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10274-10278

[4]

ALI S, 1998, J AM SOC NEPHROL, V9, P30

[5] Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels [J].

Ammala, C ;

Moorhouse, A ;

Gribble, F ;

Ashfield, R ;

Proks, P ;

Smith, PA ;

Sakura, H ;

Coles, B ;

Ashcroft, SJH ;

Ashcroft, FM .

NATURE, 1996, 379 (6565) :545-548

[6] NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines [J].

Aoki, C ;

Rhee, J ;

Lubin, M ;

Dawson, TM .

BRAIN RESEARCH, 1997, 750 (1-2) :25-40

[7] Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons [J].

Arancio, O ;

Kiebler, M ;

Lee, CJ ;

LevRam, V ;

Tsien, RY ;

Kandel, ER ;

Hawkins, RD .

CELL, 1996, 87 (06) :1025-1035

[8] Ion channels -: Exciting times for PIP2 [J].

Ashcroft, FM .

SCIENCE, 1998, 282 (5391) :1059-1060

[9] IS NITRIC-OXIDE THE RETROGRADE MESSENGER [J].

BARINAGA, M .

SCIENCE, 1991, 254 (5036) :1296-1297

[10] PIP2 and PIP as determinants for ATP inhibition of KATP channels [J].

Baukrowitz, T ;

Schulte, U ;

Oliver, D ;

Herlitze, S ;

Krauter, T ;

Tucker, SJ ;

Ruppersberg, JP ;

Fakler, B .

SCIENCE, 1998, 282 (5391) :1141-1144

← 1 2 3 4 5 6 7 8 →