Characterization of amyotrophic lateral sclerosis and frontotemporal dementia

被引：59

作者：

Lomen-Hoerth, C ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2004年 / 17卷 / 04期

关键词：

amyotrophic lateral sclerosis; frontotemporal dementia; frontotemporal lobar dementia; nonfluent progressive aphasia; semantic dementia;

D O I：

10.1159/000077167

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Amyotrophic lateral sclerosis (ALS) produces progressive weakness, muscular wasting, and spasticity leading to death from respiratory failure at a median of 3 years after onset. ALS and frontotemporal dementia (FTD) overlap in both familial and sporadic cases of ALS. When both occur in families, the affected members may have only ALS, only FTD, or both. This suggests a relationship in the cause of these disorders. We investigated the frequency of ALS in FTD patients and of FTD in ALS patients and found the overlap to be more common than had previously been reported. We report the features of cognitive impairment and pattern of motor involvement in these ALS-FTD patients, and the degree of overlap in both populations. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：337 / 341

页数：5

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