Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behavior and sensitization to amphetamine

被引:10
作者
Alttoa, A [1 ]
Harro, J [1 ]
机构
[1] Univ Tartu, Dept Psychol, Ctr Behav & Hlth Sci, EE-50410 Tartu, Estonia
关键词
amphetamine; CCK; Devazepide; L-365,260; exploratory behavior; sensitization;
D O I
10.1016/S0924-977X(03)00191-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Interactions between dopaminergic neurotransmission and cholecystokinin (CCK) in the CNS may be important in the pathogenesis of psychotic disorders and substance abuse. In this study, the effect of coadministration of the selective CCK receptor antagonists devazepide and L-365,260 (for selectively blocking CCK1 and CCK2 receptors, respectively), on the effect of amphetamine on the rat exploratory behavior, and on sensitization of locomotor response to amphetamine, were studied. Amphetamine (0.5 mg/kg) increased exploratory activity in the exploration box for 5 consecutive testing days, while devazepide (10 mug/kg) blocked and L-365,260 (10 mug/kg) enhanced amphetamine-induced stimulation of activity. Devazepide coadministration prevented the development of sensitization to amphetamine, while coadministration of L-365,260 with amphetamine potentiated the locomotor effect of a challenge dose of amphetamine. These results suggest that endogenous CCK, released during exploratory activity, shapes behavioral responses to amphetamine by acting on both receptor subtypes, and modulates the development of sensitization to amphetamine. (C) 2003 Elsevier B.V./ECNP. All rights reserved.
引用
收藏
页码:324 / 331
页数:8
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