Changes in the epidemiology of meticillin-resistant Staphylococcus aureus associated with the emergence of EMRSA-16 at a University Hospital

被引：14

作者：

Montesinos, I. ^{[1
]}

Delgado, T. ^{[1
]}

Riverol, D. ^{[1
]}

Salido, E. ^{[1
]}

Miguel, M. A. ^{[1
]}

Jimenez, A. ^{[1
]}

Sierra, A. ^{[1
]}

机构：

[1] Hosp Univ Canarias, Infect Control & Microbiol Dept, San Cristobal la Laguna 38230, Canary Islands, Spain

来源：

JOURNAL OF HOSPITAL INFECTION | 2006年 / 64卷 / 03期

关键词：

MRSA; EMRSA-16; PFGE; MLST; SCCmec typing;

D O I：

10.1016/j.jhin.2006.07.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study investigated the molecular epidemiology of meticillin-resistant Staphylococcus aureus (MRSA) in the University Hospital. of the Canary Islands (HUC) in order to evaluate epidermiological changes over a six-year period. Clinical and epidemiological data were collected between May 2000 and December 2003, and isolates were subjected to pulsed-field get electrophoresis (PFGE), multi-locus sequence typing (MLST), SCCmec typing and spa typing. Since 2000, the rate of MRSA infections has increased at the HUC, coinciding with the emergence and spread of the EMRSA-16 clone (ST36-MRSA-11) and replacement of the Iberian clone (ST247-MRSA-1). Genotypic changes were associated with changes in the epidemiological profile. The mean age and proportion of patients over 60 years old (P = 0.01) and the proportion of respiratory infections (P = 0.001) increased significantly. Gentamicin and tetracycline susceptibility of MRSA isolates increased (P < 0.001) following the emergence of EMRSA-16. Combining PFGE, SCCmec and MLST has been instrumental in understanding these changes and defining the clones circulating in the HUC patient population. (c) 2006 The Hospital. Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：257 / 263

页数：7

共 26 条

[1] Clonal and antibiotic resistance profiles of methicillin-resistant Staphylococcus aureus (MRSA) from a Portuguese hospital over time [J].