The genetic architecture of quantitative traits:: lessons from Drosophila

被引：163

作者：

Mackay, TFC ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.gde.2004.04.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Understanding the genetic architecture of quantitative traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate quantitative traits, and large numbers of QTLs with sex-, environment- and genotype-specific effects. Multiple molecular polymorphisms in regulatory regions of candidate genes are often associated with variation for complex traits. These observations offer valuable lessons for understanding the genetic basis of variation for complex traits in other organisms, including humans.

引用

页码：253 / 257

页数：5

共 50 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2]

Anholt RRH, 1996, GENETICS, V143, P293

[3] The genetic architecture of odor-guided behavior in Drosophila:: epistasis and the transcriptome [J].

Anholt, RRH ;

Dilda, CL ;

Chang, S ;

Fanara, JJ ;

Kulkarni, NH ;

Ganguly, I ;

Rollmann, SM ;

Kamdar, KP ;

Mackay, TFC .

NATURE GENETICS, 2003, 35 (02) :180-184

[4]

AQUADRO CF, 1986, GENETICS, V114, P1165

[5]

Ashburner M., 1989, DROSOPHILA LAB HDB

[6] Localization of apical epithelial determinants by the basolateral PDZ protein Scribble [J].

Bilder, D ;

Perrimon, N .

NATURE, 2000, 403 (6770) :676-680

[7]

CHOUDHARY M, 1991, GENETICS, V129, P481

[8] Dopa decarboxylase (Ddc) affects variation in Drosophila longevity [J].

De Luca, M ;

Roshina, NV ;

Geiger-Thornsberry, GL ;

Lyman, RF ;

Pasyukova, EG ;

Mackay, TFC .

NATURE GENETICS, 2003, 34 (04) :429-433

[9]

Dilda CL, 2002, GENETICS, V162, P1655

[10]

Doerge RW, 1996, GENETICS, V142, P285

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