Regulation of bovine satellite cell proliferation and differentiation by insulin and triiodothyronine

被引:35
作者
Cassar-Malek, I [1 ]
Langlois, N [1 ]
Picard, B [1 ]
Geay, Y [1 ]
机构
[1] INRA, Ctr Clermont Ferrand Theix, Unite Rech Herbivores, Equipe Croissance & Metab Muscle, F-63122 St Genes Champanelle, France
关键词
D O I
10.1016/S0739-7240(99)00055-7
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Satellite cells activity contributes to postnatal muscle growth. Herein, we have studied the respective influence of insulin and triiodothyronine (T3) on the proliferation and differentiation of primary bovine satellite cells isolated from Semitendinosus muscle of Montebeliard steers. Under basal conditions, satellite cells proliferated until the fifth day of culture, began to fuse into myotubes and expressed differentiation markers such as connectin, myogenin, and myosin heavy chain (MHC) isoforms. Insulin behaved as an effective mitogen. Moreover, it promoted extensive myotube formation and enhanced differentiation as shown by an increase in the accumulation of differentiation markers. Maximal differentiation occurred with insulin physiological range concentrations. A delay in the stimulation of differentiation was registered with a high dose that promoted maximal proliferation. Conversely, T3 decreased cell proliferation in a dose-dependent manner. In addition, fusion and biochemical differentiation (accumulation of connectin, MyoD1, myogenin, and myosin heavy chain isoforms) were also enhanced. Bovine satellite cells seemed to respond differentially to insulin and T3 for proliferation. Interestingly, both hormones displayed a myogenic influence. Our observations suggest that both hormones could influence bovine satellite cells in vivo and contribute to the regulation of postnatal muscle growth. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:373 / 388
页数:16
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