Asymmetric catalytic Friedel-Crafts reaction of silyl enol ethers with fluoral: A possible mechanism of the Mukaiyama-Aldol reactions

被引：54

作者：

Ishii, A ^{[1
]}

Kojima, J ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 1528582, Japan

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 12期

关键词：

D O I：

10.1021/ol990330s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The catalytic asymmetric Friedel-Crafts reaction of silyl enol ethers with fluoral proceeds under Mukaiyama-aldol conditions to give silyl enol ether products. The sequential diastereoselective reactions of the resultant silyl enol ethers with electrophiles provide highly enantiopure functionalized organofluorine compounds of material and pharmaceutical interest.

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页码：2013 / 2016

页数：4

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