Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice

被引：18

作者：

Bovenschen, N

Dijk, KW

Havekes, LM

Mertens, K

Vlijmen, BJM

机构：

[1] CLB, Sanquin Res, Dept Plasma Prot, NL-1066 CX Amsterdam, Netherlands

[2] TNO Prevent & Hlth, Gaubius Lab, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Internal Med, Leiden, Netherlands

[5] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands

[6] Univ Utrecht, UIPS, Utrecht, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 126卷 / 05期

关键词：

factor VIII; very low-density lipoprotein receptor; low-density lipoprotein receptor-related protein; knockout mice; clearance;

D O I：

10.1111/j.1365-2141.2004.05093.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low-density lipoprotein receptor-related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo. Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro. We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination. VLDLR-/- mice displayed normal plasma FVIII, whereas VLDLR-/- LRP- double-knockout mice had slightly increased FVIII compared with LRP-deficient mice. Remarkably, VLDLR deficiency slightly accelerated FVIII clearance. Adenovirus-mediated overexpression of VLDLR did not lower plasma FVIII in LRP-deficient mice. We conclude that VLDLR does not act in concert with LRP in FVIII clearance in vivo.

引用

页码：722 / 725

页数：4

共 12 条

[1] Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency [J].