Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomography

被引：13

作者：

Ishiwata, K

Mizuno, M

Kimura, Y

Kawamura, K

Oda, K

Sasaki, T

Nakamura, Y

Muraoka, I

Ishii, K

机构：

[1] Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 1730022, Japan

[2] Waseda Univ, Grad Sch Human Sci, Tokorozawa, Saitama 3591192, Japan

[3] SHI Accelerator Serv Co Ltd, Shinagawa Ku, Tokyo 1410032, Japan

[4] Waseda Univ, Sch Sport Sci, Tokorozawa, Saitama 3591192, Japan

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 07期

基金：

日本学术振兴会;

关键词：

adenosine A(2A) receptor; C-11]TMSX; muscle; human; positron emission tomography;

D O I：

10.1016/j.nucmedbio.2004.06.003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We examined the potential of [7-methyl-C-11]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([C-11]TMSX) for the assessment of adenosine A(2A) receptors in muscle. In rodents, specific binding of [C-11]TMSX was observed in muscle and heart by blockade with A(2A)-selective CSC and non-selective theophylline, but not with A(1)-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [C-11]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：949 / 956

页数：8

共 31 条

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