Anemia of inflammation: the cytokine-hepcidin link

被引：267

作者：

Andrews, NC

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 09期

关键词：

D O I：

10.1172/JCI200421441

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder (see the related article beginning on page 1271).

引用

页码：1251 / 1253

页数：3

共 18 条

[1] Decreased hepcidin mRNA expression in thalassemic mice
Adamsky, K
Weizer, O
Amariglio, N
Breda, L
Harmelin, A
Rivella, S
Rachmilewitz, E
Rechavi, G
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2004, 124 (01) : 123 - 124
[2] CARTWRIGHT G. E., 1966, SEMINARS HEMATOL, V3, P351
[3] ANAEMIA OF CHRONIC DISORDERS
CARTWRIGHT, GE
LEE, GR
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1971, 21 (02) : 147 - +
[4] CARTWRIGHT GE, 1952, ADV INTERNAL MED, V5, P165
[5] Serum hepcidin in clinical specimens
Dallalio, G
Fleury, T
Means, RT
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2003, 122 (06) : 996 - 1000
[6] The copper and non-hemoglobinous iron contents of the blood serum in disease
Locke, A
Main, ER
Rosbash, DO
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1932, 11 (03) : 527 - 542
[7] Cytokine-mediated regulation of iron transport in human monocytic cells
Ludwiczek, S
Aigner, E
Theurl, I
Weiss, G
[J]. BLOOD, 2003, 101 (10) : 4148 - 4154
[8] PATHOGENESIS OF THE ANEMIA OF CHRONIC DISEASE - A CYTOKINE-MEDIATED ANEMIA
MEANS, RT
[J]. STEM CELLS, 1995, 13 (01) : 32 - 37
[9] Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
Muckenthaler, M
Roy, CN
Custodio, AO
Miñana, B
deGraaf, J
Montross, LK
Andrews, NC
Hentze, MW
[J]. NATURE GENETICS, 2003, 34 (01) : 102 - 107
[10] Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E
Valore, EV
Territo, M
Schiller, G
Lichtenstein, A
Ganz, T
[J]. BLOOD, 2003, 101 (07) : 2461 - 2463

← 1 2 →