Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy

被引:61
作者
Cheng, XL
Filiaggi, M
Roscoe, SG
机构
[1] Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada
[2] Dalhousie Univ, Dept Appl Oral Sci, Halifax, NS B3H 3J5, Canada
[3] Dalhousie Univ, Sch Biomed Engn, Halifax, NS B3H 3J5, Canada
关键词
hydroxyapatite; cacium phosphate; titanium alloy; protein; electrochemical incorporation;
D O I
10.1016/j.biomaterials.2003.12.045
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4 V surface. Electrochemically assisted co-precipitation of BSA/ brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70 h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5395 / 5403
页数:9
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