Mangiferin Regulates Interleukin-6 and Cystathionine-b-Synthase in Lipopolysaccharide-Induced Brain Injury

被引：37

作者：

Fu, Yan-Yan ^{[1
]}

Zhang, Fang ^{[1
]}

Zhang, Lei ^{[2
]}

Liu, Hong-Zhi ^{[1
]}

Zhao, Zi-Ming ^{[3
]}

Wen, Xiang-Ru ^{[1
,4
]}

Wu, Jian ^{[1
]}

Qi, Da-Shi ^{[1
]}

Sun, Ying ^{[2
]}

Du, Yang ^{[1
]}

Dong, Hong-Yan ^{[1
]}

Liu, Yong-Hai ^{[2
]}

Song, Yuan-Jian ^{[1
,5
]}

机构：

[1] Xuzhou Med Coll, Dept Neurobiol, Neurobiol Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China

[2] Xuzhou Med Coll, Dept Neurol, Affiliated Hosp, Xuzhou 221004, Jiangsu, Peoples R China

[3] Xuzhou Med Coll, Sch Pharm, Xuzhou 221004, Jiangsu, Peoples R China

[4] Xuzhou Med Coll, Sch Basic Educ Sci, Xuzhou 221004, Jiangsu, Peoples R China

[5] Xuzhou Med Coll, Jiangsu Key Lab Brain Dis Bioinformat, Xuzhou 221004, Jiangsu, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2014年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Mangiferin; Lipopolysaccharide; Brain; Interleukin-6; Cystathionine beta-synthase; INDUCED MICROGLIAL ACTIVATION; PROSTAGLANDIN E-2 PRODUCTION; HYDROGEN-SULFIDE; EXPRESSION; NEUROPROTECTION; PROTECTS; INSIGHTS; MEDIATOR; DEFICITS; CELLS;

D O I：

10.1007/s10571-014-0039-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mangiferin has been extensively applied in different fields due to its anti-inflammatory properties. However, the precise mechanism used by mangiferin on lipopolysaccharide (LPS)-induced inflammation has not been elucidated. Here, we discuss the potential mechanism of mangiferin during a LPS-induced brain injury. Brain injury was induced in ICR mice via intraperitoneal LPS injection (5 mg/kg). Open- and closed-field tests were used to detect the behaviors of mice, while immunoblotting was performed to measure the expression of interleukin-6 (IL-6) and cystathionine-b-synthase (CBS) in the hippocampus after mangiferin was orally administered (p.o.). Mangiferin relieved LPS-induced sickness 6 and 24 h after LPS injection; in addition, this compound suppressed LPS-induced IL-6 production after 24 h of LPS induction as well as the downregulation of LPS-induced CBS expression after 6 and 24 h of LPS treatment in the hippocampus. Therefore, mangiferin attenuated sickness behavior by regulating the expression of IL-6 and CBS.

引用

页码：651 / 657

页数：7

共 30 条

[1]

Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells [J].