Clinical Applications of Skin Substitutes

被引：62

作者：

Nyame, Theodore T. ^{[1
]}

Chiang, H. Abraham ^{[2
]}

Orgill, Dennis P. ^{[3
]}

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Surg, Div Plast & Reconstruct Surg, Boston, MA 02115 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2014年 / 94卷 / 04期

关键词：

Skin substitutes; Allografts; Dermal templates; Chronic wounds; Foot ulcers; DIABETIC FOOT ULCERS; VENOUS LEG ULCERS; APLIGRAF(R); MANAGEMENT; BURNS; RECONSTRUCTION; MECHANISMS; GRAFTSKIN; EPIDERMIS;

D O I：

10.1016/j.suc.2014.05.013

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

A unique understanding of the components of mammalian skin has led to the development of numerous skin substitutes. These skin substitutes attempt to compensate for functional and physiologic deficits present in damaged tissue. Skin substitutes, when appropriately applied in optimized settings, offer a promising solution to difficult wound management. The body of literature on skin substitutes increases as the understanding of tissue engineering and molecular biology expands. Given the high cost of these products, future randomized large prospective studies are needed to guide the clinical applications of skin substitutes.

引用

页码：839 / +

页数：13

共 57 条

[1]

Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent [J].