Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites

被引:104
作者
Depinay, Nadya [1 ]
Hacini, Feriel [1 ]
Beghdadi, Walid [1 ]
Peronet, Roger [1 ]
Mecheri, Salaheddine [1 ]
机构
[1] Inst Pasteur, Unite Reponses Prococes Parasites & Immunopathol, F-75724 Paris 15, France
关键词
D O I
10.4049/jimmunol.176.7.4141
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
While probing host skin to search for blood vessels, the female Anopheles mosquito delivers Plasmodium parasites in the presence of saliva. Saliva from various blood-feeding vectors which contains several pharmacologically active components is believed to facilitate blood feeding as well as parasite transmission to the host. Recently, we found that mosquito saliva has the capacity to activate dermal mast cells and to induce local inflammatory cell influx. Our main objective in the present work is to investigate whether saliva, through mosquito bites, controls the magnitude of Ag-specific immune responses and whether this control is dependent on the mast cell-mediated inflammatory response. Using a mast cell knockin mouse model, we found that mosquito bites consistently induced MIP-2 in the skin and IL-10 in draining lymph nodes, and down-regulate Ag-specific T cell responses by a mechanism dependent on mast cells and mediated by IL-10. Our results provide evidence for new mechanisms which may operate during Plasmodium parasite transmission by mosquito bites.
引用
收藏
页码:4141 / 4146
页数:6
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