Vaccination of chickens against H5N1 avian influenza in the face of an outbreak interrupts virus transmission

被引:146
作者
Ellis, TM [1 ]
Leung, CYHC
Chow, MKW
Bissett, LA
Wong, W
Guan, Y
Peiris, JSM
机构
[1] Agr Fisheries & Conservat Dept, Tai Lung Vet Lab, Sheung Shui, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
[3] Agr Fisheries & Conservat Dept, Livestock Farm Div, Sheung Shui, Hong Kong, Peoples R China
关键词
D O I
10.1080/03079450410001724012
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Vaccination of chickens with a commercially available killed H5N2 vaccine was being evaluated as an additional tool to enhanced biosecurity measures and intensive surveillance for control of highly pathogenic avian influenza subtype H5N1 disease in Hong Kong in 2002. In December 2002 to January 2003, there were outbreaks of H5N1 disease in waterfowl in two recreational parks, wild water birds, several poultry markets and five chicken farms. In addition to quarantine, depopulation of the affected sheds and increased biosecurity, vaccination of the unaffected sheds and surrounding unvaccinated farms was undertaken on three farms. In at least two farms, infection spread to the recently vaccinated sheds with low rates of H5N1 mortality in sheds when the chickens were between 9 and 18 days post-vaccination. However, after 18 days post-vaccination no more deaths from H5N1 avian influenza occurred and intensive monitoring by virus culture on these farms showed no evidence of asymptomatic shedding of the virus. This provides evidence that H5 vaccine can interrupt virus transmission in a field setting.
引用
收藏
页码:405 / 412
页数:8
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