The isolation and crystal structure of a cyclic selenenate ester derived from Bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its glutathione peroxidase-like activity

被引：89

作者：

Zade, SS ^{[1
]}

Singh, HB

Butcher, RJ

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

[2] Howard Univ, Dept Chem, Washington, DC 20059 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期

关键词：

enzyme catalysis; esters; halogenation; selenium; structure elucidation;

D O I：

10.1002/anie.200460380

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme mimicry: Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular non-bonding Se⋯O interaction. Both 1 and 2 show excellent glutathione peroxidase-like catalytic activity.

引用

页码：4513 / 4515

页数：3

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