Effect of aging on nitric oxide production by rat alveolar macrophages

被引：23

作者：

Koike, E

Kobayashi, T ^{[1
]}

Mochitate, K

Murakami, M

机构：

[1] Natl Inst Environm Studies, Environm Hlth Sci Div, Tsukuba, Ibaraki 3050053, Japan

[2] Univ Tsukuba, Dept Med, Tsukuba, Ibaraki 3058575, Japan

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 07期

关键词：

aging; alveolar macrophage; nitric oxide; lymph node cell; bronchoalveolar lavage fluid;

D O I：

10.1016/S0531-5565(99)00061-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Nitric oxide (NO) plays an important role in alveolar macrophages (AM)-mediated defense against infection. The elderly become highly susceptible to respiratory tract infection. Inhibition of NO production significantly suppresses defense against infections. Therefore, it is necessary to elucidate the effect of senescence on NO production of AM. The alveolar microenvironment and lymphocytes affect NO production by AM. We examined whether changes in the alveolar microenvironment, lymphocytes, or AM brought about by aging affect NO production by AM. Bronchoalveolar lavage fluid was used as a substitute for the alveolar microenvironment. The results showed that NO production by AM activated by lymph node cells in bronchoalveolar lavage fluid from old rats in response to concanavalin A decreased compared with that of young rats. AM from aged rats produced less NO than AM from young rats. Bronchoalveolar lavage fluid and lymph node cells from aged rats had no effect on the amount of NO produced by AM. Therefore, age-associated decrease in the functional capacity of AM plays a central role in the decrease of NO production. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：889 / 894

页数：6

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