Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis

被引：46

作者：

Suzuki, Toshiharu ^{[1
]}

Araki, Yoichi ^{[1
]}

Yamamoto, Tohru ^{[1
]}

Nakaya, Tadashi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2006年 / 139卷 / 06期

关键词：

Alzheimer's disease; amyloid beta-protein precursor; cargo-receptor; kinesin; membrane trafficking; neurodegeneration;

D O I：

10.1093/jb/mvj121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a common neurodegenerative disorder that causes senile dementia. The pathological characteristics are the appearance of neurofibrillary tangles comprising abnormally phosphorylated tau and senile plaques composed of amyloid P-protein depositions. Amyloid P-protein precursor (APP) and presenilin (PS) are known to be causative genes of familial AD. Recent analyses have documented that APP functions in the axonal transport of vesicles and PS regulates intracellular protein trafficking. Dystrophic neurites, in which APP and Alcadein accumulate in swollen axons, are also observed in AD brain. These pathological characteristics and the features of AD-related proteins suggest that AD is a disease of the vesicular transport system. Here we review recent progress of research on AD pathogenesis from the viewpoint of membrane trafficking.

引用

页码：949 / 955

页数：7

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