Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

被引：156

作者：

Wojciechowski, Wojciech ^{[1
]}

Harris, David P. ^{[1
]}

Sprague, Frank ^{[1
]}

Mousseau, Betty ^{[1
]}

Makris, Melissa ^{[1
]}

Kusser, Kim ^{[1
]}

Honjo, Tasuko ^{[2
]}

Mohrs, Katie ^{[1
]}

Mohrs, Markus ^{[1
]}

Randall, Troy ^{[1
]}

Lund, Frances E. ^{[1
]}

机构：

[1] Trudeau Inst, Saranac Lake, NY 12983 USA

[2] Kyoto Univ, Dept Immunol & Genom Med, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan

来源：

IMMUNITY | 2009年 / 30卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; TUMOR-NECROSIS-FACTOR; IFN-GAMMA PRODUCTION; MEMORY CD4 CELLS; T-CELLS; IN-VIVO; NEMATOSPIROIDES-DUBIUS; HELMINTH INFECTION; TNF-ALPHA; MICE;

D O I：

10.1016/j.immuni.2009.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. Polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses.

引用

页码：421 / 433

页数：13

共 53 条

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