Enzymetically Regulating the Self-Healing of Protein Hydrogels with High Healing Efficiency

被引：60

作者：

Gao, Yuzhou ^{[1
]}

Luo, Quan ^{[1
]}

Qiao, Shanpeng ^{[1
]}

Wang, Liang ^{[1
]}

Dong, Zeyuan ^{[1
]}

Xu, Jiayun ^{[1
]}

Liu, Junqiu ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 35期

关键词：

dynamic covalent bonds; enzyme mediation; glucose oxidase; protein hydrogels; self-healing; MICROVASCULAR NETWORKS; POLYMERS; COMPOSITES;

D O I：

10.1002/anie.201404531

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Enzyme-mediated self-healing of dynamic covalent bond-driven protein hydrogels was realized by the synergy of two enzymes, glucose oxidase (GOX) and catalase (CAT). The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self-healing protein hydrogel system. The enzyme-mediated protein hydrogels exhibit excellent self-healing properties with 100% recovery. The self-healing process was reversible and effective with an external glucose stimulus at room temperature.

引用

页码：9343 / 9346

页数：4

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