Regulatory T cells and Toll-like receptors: What is the missing link?

被引：51

作者：

Dai, Jie ^{[1
]}

Liu, Bei ^{[2
]}

Li, Zihai ^{[2
]}

机构：

[1] Schering Plough Biopharma, Palo Alto, CA 94304 USA

[2] Univ Connecticut, Sch Med, Neag Comprehens Canc Ctr, Ctr Immunotherapy Canc & Infect Dis,Dept Immunol, Farmington, CT 06030 USA

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2009年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Heat shock protein; gp96; Toll-like receptor; TLR4; Regulatory T cells; FoxP3; KINASE-C-THETA; ADAPTIVE IMMUNE-RESPONSES; SURFACE EXPRESSION; DENDRITIC CELLS; PKC-THETA; DIFFERENTIAL REGULATION; INNATE IMMUNITY; CUTTING EDGE; B-CELLS; PROTEIN;

D O I：

10.1016/j.intimp.2009.01.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are critical sensors for microbial products and are important in initiating both innate and adaptive immune defenses against pathogens. Emerging evidence suggests that TLRs are also expressed by regulatory T cells (Treg) that constitute an important immune suppressive cellular mechanism to curtail TLR hyperactivity to avoid sepsis and autoimmune diseases. This review brings up to dale on the expression of functional TLRs on Treg and the functional impact of TLR activation on Treg biology. We argue that the suppressive function of Treg can be augmented or attenuated depending on the nature of TLR stimulations. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：528 / 533

页数：6

共 72 条

[1] Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages [J].