Lecticans: organizers of the brain extracellular matrix

被引：507

作者：

Yamaguchi, Y ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2000年 / 57卷 / 02期

关键词：

proteoglycan; chondroitin sulfate; extracellular matrix; nervous system; neurite outgrowth; axon regeneration;

D O I：

10.1007/PL00000690

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lecticans are a family of chondroitin sulfate proteoglycans, encompassing aggrecan, versican, neurocan and brevican. These proteoglycans are characterized by the presence of a hyaluronan-binding domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular mall ix molecules. In adult brain, lecticans are thought to interact with hyaluronan and tenascin-li to form a ternary complex. We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'.

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页码：276 / 289

页数：14

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