Synthesis of [F-18]fluoroetanidazole: A potential new tracer for imaging hypoxia

被引：53

作者：

Tewson, TJ

机构：

[1] Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle

[2] NW041 University Medical Center, Imaging Research Laboratory, University of Washington, Seattle

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 08期

关键词：

hypoxia; nitroimidazoles; fluorine-18; fluoroethylamine; active esters;

D O I：

10.1016/S0969-8051(97)00135-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A method has been developed for the synthesis of [F-18]fluoroetanidazole, a potential tracer for imaging hypoxia with positron emission tomography. The compound is prepared by an active ester coupling reaction between the 2,3,5,6-tetrafluorophenyl ester of 2-nitroimidazole acetic acid and [F-18]fluoroethylamine. [F-18]Fluoroethylamine is prepared from N-[2-(toluene-4-sulfonyloxy)-ethyl]-phthalimide and [F-18]fluoride and purified by distillation. The overall reaction takes about 90 min and gives a yield, uncorrected, of about 25%. Purification on a reversed-phase column is straightforward. (C) 1997 Elsevier Science Inc.

引用

页码：755 / 760

页数：6

共 32 条

[1] POTENTIAL RADIOSENSITIZING AGENTS - DINITROIMIDAZOLES [J].