Opinion - Chromatin in pluripotent embryonic stem cells and differentiation

被引：528

作者：

Meshorer, Eran ^{[1
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 07期

基金：

美国国家卫生研究院;

关键词：

H3; LYSINE-9; METHYLATION; DNA METHYLATION; GENE-EXPRESSION; SELF-RENEWAL; NUCLEAR ARCHITECTURE; NEURAL INDUCTION; HISTONE; GENOME; ORGANIZATION; REPLICATION;

D O I：

10.1038/nrm1938

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

引用

页码：540 / 546

页数：7

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