DNA repair pathways in drug resistance in melanoma

被引：44

作者：

Bradbury, PA ^{[1
]}

Middleton, MR ^{[1
]}

机构：

[1] Churchill Hosp, Canc Res UK, Med Oncol Unit, Oxford, England

来源：

ANTI-CANCER DRUGS | 2004年 / 15卷 / 05期

关键词：

DNA repair pathways; drug resistance; melanoma;

D O I：

10.1097/01.cad.0000127665.74096.93

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic melanoma has a poor prognosis due to resistance to multiple chemotherapy regimens. The mainstay of treatment remains dacarbazine, with cisplatin being a commonly used alternative. Melanoma displays marked resistance to the DNA-damaging effects of these drugs. Intrinsic and acquired resistance involves multiple cellular pathways of damage recognition, repair and apoptosis. Increased understanding of these pathways is identifying novel targets that it is hoped will make inroads into the treatment of this lethal disease. (C) 2004 Lippincott Williams Wilkins.

引用

页码：421 / 426

页数：6

共 62 条

[1]

An JB, 2003, CLIN CANCER RES, V9, P4537

[2]

Atkins MB, 2002, CLIN CANCER RES, V8, P3075

[3]

AYI TC, 1992, CANCER RES, V52, P6423

[4] PHASE-II TRIAL OF DOCETAXEL IN PATIENTS WITH ADVANCED CUTANEOUS MALIGNANT-MELANOMA PREVIOUSLY UNTREATED WITH CHEMOTHERAPY [J].

BEDIKIAN, AY ;

WEISS, GR ;

LEGHA, SS ;

BURRIS, HA ;

ECKARDT, JR ;

JENKINS, J ;

ETON, O ;

BUZAID, AC ;

SMETZER, L ;

VONHOFF, DD ;

BENJAMIN, RS .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (12) :2895-2899

[5]

Bhoumik A, 2001, CLIN CANCER RES, V7, P331

[6] Modification of non-conservative double-strand break (DSB) rejoining activity after the induction of cisplatin resistance in human tumour cells [J].

Britten, RA ;

Kuny, S ;

Perdue, S .

BRITISH JOURNAL OF CANCER, 1999, 79 (5-6) :843-849

[7] Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J].

Cameron, EE ;

Bachman, KE ;

Myöhänen, S ;

Herman, JG ;

Baylin, SB .

NATURE GENETICS, 1999, 21 (01) :103-107

[8] Phase III multicenter randomized trial of the dartmouth regimen versus dacarbazine in patients with metastatic melanoma [J].

Chapman, PB ;

Einhorn, LH ;

Meyers, ML ;

Saxman, S ;

Destro, AN ;

Panageas, KS ;

Begg, CB ;

Agarwala, SS ;

Schuchter, LM ;

Ernstoff, MS ;

Houghton, AN ;

Kirkwood, JM .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (09) :2745-2751

[9]

Chen Jianimin, 1992, Chinese Medical Sciences Journal, V7, P187

[10]

CHEN JM, 1992, CARCINOGENESIS, V13, P1503

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