Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay

被引：74

作者：

Risa, J

Risa, A

Adsersen, A

Gauguin, B

Stafford, GI

van Staden, J

Jäger, AK

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen 0, Denmark

[2] Univ Natal Pietermaritzburg, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 93卷 / 2-3期

基金：

新加坡国家研究基金会;

关键词：

convulsions; epilepsy; GABA(A)-benzodiazepine receptor assay; South Africa; traditional medicine;

D O I：

10.1016/j.jep.2004.01.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and ethanol extracts of 43 plants that are traditionally used to treat against epilepsy and convulsions, were tested in the GABA(A)-benzodiazepine receptor binding assay, where the binding of H-3-Ro 15-1788 (flumazenil) to the benzodiazepine site is measured. The GABAA-benzodiazepine receptor complex is involved in epilepsy and convulsions. Out of the 118 extracts tested, one aqueous and 18 ethanol extracts showed activity. The most active extracts were the ethanolic leaf extracts of Rhus tridentata, Rhus rehmanniana and Hoslundia opposita and the ethanolic corm extract of Hypoxis colchicifolia, which all showed good dose-dependent activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：177 / 182

页数：6

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