Mild cognitive impairment -: beyond controversies, towards a consensus:: report of the International Working Group on Mild Cognitive Impairment

被引：3758

作者：

Winblad, B

Palmer, K

Kivipelto, M

Jelic, V

Fratiglioni, L

Wahlund, LO

Nordberg, A

Bäckman, L

Albert, M

Almkvist, O

Arai, H

Basun, H

Blennow, K

de Leon, M

DeCarli, C

Erkinjuntti, T

Giacobini, E

Graff, C

Hardy, J

Jack, C

Jorm, A

Ritchie, K

van Duijn, C

Visser, P

Petersen, RC

机构：

[1] Karolinska Inst, Aging Res Ctr, Div Geriatr Epidemiol, Neurotec Dept, S-11382 Stockholm, Sweden

[2] Karolinska Inst, Neurotec Dept, Div Geriatr Med, Stockholm, Sweden

[3] Karolinska Inst, Neurotec Dept, Div Mol Neuropharmacol, Stockholm, Sweden

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] Tohoku Univ, Grad Sch Med, Dept Geriatr & Complementary Med, Sendai, Miyagi 980, Japan

[6] Uppsala Univ, Dept Publ Hlth Geriatr, Uppsala, Sweden

[7] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Neurosci, Gothenburg, Sweden

[8] NYU, Sch Med, Ctr Brain Hlth, New York, NY USA

[9] Univ Calif Davis, Alzheimers Dis Ctr, Dept Neurol, Sacramento, CA 95817 USA

[10] Helsinki Univ Hosp, Dept Clin Neurosci, Helsinki, Finland

[11] Univ Geneva, Sch Med, Dept Geriatr, CH-1211 Geneva 4, Switzerland

[12] Karolinska Inst, Neurotec Dept, Div Expt Geriatr, Stockholm, Sweden

[13] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[14] Mayo Clin, Dept Diagnost Radiol, Rochester, MN USA

[15] Mayo Clin, MR Res Lab, Rochester, MN USA

[16] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT, Australia

[17] INSERM, Dept Nervous Syst Pathol, Montpellier, France

[18] Erasmus Med Ctr, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[19] Erasmus Med Ctr, Dept Clin Genet, Rotterdam, Netherlands

[20] Univ Maastricht, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[21] Mayo Clin, Dept Neurol, Rochester, MN USA

来源：

JOURNAL OF INTERNAL MEDICINE | 2004年 / 256卷 / 03期

关键词：

MCI; consensus; mild cognitive impairment; definition; clinical criteria; pre-clinical dementia; Alzheimer's disease;

D O I：

10.1111/j.1365-2796.2004.01380.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The First Key Symposium was held in Stockholm, Sweden, 2-5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild Cognitive Impairment (MCI). A multidisciplinary, international group of experts discussed the current status and future directions of MCI, with regard to clinical presentation, cognitive and functional assessment, and the role of neuroimaging, biomarkers and genetics. Agreement on new perspectives, as well as recommendations for management and future research were discussed by the international working group. The specific recommendations for the general MCI criteria include the following: (i) the person is neither normal nor demented; (ii) there is evidence of cognitive deterioration shown by either objectively measured decline over time and/or subjective report of decline by self and/or informant in conjunction with objective cognitive deficits; and (iii) activities of daily living are preserved and complex instrumental functions are either intact or minimally impaired.

引用

页码：240 / 246

页数：7