Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

被引：29

作者：

Chiu, Ya-Ling ^{[1
]}

Chen, Mei-Chin ^{[1
]}

Chen, Chun-Yu ^{[1
]}

Lee, Po-Wei ^{[1
]}

Mi, Fwu-Long ^{[2
]}

Jeng, U-Ser ^{[3
]}

Chen, Hsin-Lung ^{[1
]}

Sung, Hsing-Wen ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

[2] Vanung Univ, Dept Biotechnol, Chungli Taoyuan, Taiwan

[3] NSRRC, Hsinchu, Taiwan

来源：

SOFT MATTER | 2009年 / 5卷 / 05期

关键词：

GLASS-TRANSITION;

D O I：

10.1039/b818906d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

引用

页码：962 / 965

页数：4

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