LINE drive: Retrotransposition and genome instability

被引：161

作者：

Kazazian, HH ^{[1
]}

Goodier, JL ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19105 USA

来源：

CELL | 2002年 / 110卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(02)00868-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that Ll retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.

引用

页码：277 / 280

页数：4

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