Adjuvant effect of quaternary ammonium compounds in a murine model

被引：15

作者：

Larsen, ST ^{[1
]}

Hansen, R ^{[1
]}

Hammer, M ^{[1
]}

Tegner, U ^{[1
]}

Poulsen, OM ^{[1
]}

Nielsen, GD ^{[1
]}

机构：

[1] Natl Inst Occupat Hlth, Dept Chem Working Environm, DK-2100 Copenhagen, Denmark

来源：

TOXICOLOGY LETTERS | 2004年 / 151卷 / 02期

关键词：

quaternary ammonium compound; immunological adjuvant; IgE; IgG;

D O I：

10.1016/j.toxlet.2004.03.008

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

It has been suggested that occupational exposure to quaternary ammonium compounds (QACs) may promote the development of allergic airway diseases. In this study, hazard identifications of the adjuvant effect of cetylpyridinium chloride (CPC), dimethy1dioctadecylammonium bromide (DDA), hexadecyltrimethylammonium bromide (HTA), and tetraethylammonium chloride (TEA) were performed in a screening bioassay. Female BALB/c mice were injected subcutaneously with the model allergen ovalbumin (OVA) alone or together with different quantities of one of the QAC test compounds. After one or two boosters, levels of OVA-specific IgE, IgG I and IgG2a antibodies were measured in sera. CPC and DDA increased IgE and IgG I antibody production, respectively, compared to the OVA control group, whereas HTA and TEA showed no adjuvant effect. Nevertheless, when TEA was given in combination with DDA, the adjuvant effect was up to six-fold higher than the adjuvant effect of DDA alone. Only DDA had a statistically significant adjuvant effect on IgG2a antibody levels. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：389 / 398

页数：10

共 39 条

[1] Enhancement of allergic inflammation by diesel exhaust particles: permissive role of reactive oxygen species [J].

Casillas, AM ;

Hiura, T ;

Li, N ;

Nel, AE .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1999, 83 (06) :624-629

[2] Study of adjuvant effect of model surfactants from the groups of alkyl sulfates, alkylbenzene sulfonates, alcohol ethoxylates and soaps [J].

Clausen, SK ;

Sobhani, S ;

Poulsen, OM ;

Poulsen, LK ;

Nielsen, GD .

FOOD AND CHEMICAL TOXICOLOGY, 2000, 38 (11) :1065-1074

[3] Development of sensitisation or tolerance following repeated OVA inhalation in BALB/cJ mice.: Dose-dependency and modulation by the Al(OH)3 adjuvant [J].

Clausen, SK ;

Bergqvist, M ;

Poulsen, LK ;

Poulsen, OM ;

Nielsen, GD .

TOXICOLOGY, 2003, 184 (01) :51-68

[4] Induction of TH1 and TH2 CD4+ T cell responses: The alternative approaches [J].

Constant, SL ;

Bottomly, K .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :297-322

[5]

Corry DB, 1999, NATURE, V402, pB18

[6] Divergent antibody isotype responses induced in mice by systemic exposure to proteins: a comparison of ovalbumin with bovine serum albumin [J].

Dearman, RJ ;

Caddick, H ;

Basketter, DA ;

Kimber, I .

FOOD AND CHEMICAL TOXICOLOGY, 2000, 38 (04) :351-360

[7] REGIONAL AND SYSTEMIC IMMUNE-RESPONSES TO TRINITROPHENYL DERIVATIVES AFTER INTRANASAL AND SUBCUTANEOUS SENSITIZATION OF MICE [J].

ENANDER, I ;

AHLSTEDT, S ;

NYGREN, H .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 75 (01) :37-43

[8] IL-4 PRODUCTION IN MEDIASTINAL LYMPH-NODE CELLS IN MICE INTRATRACHEALLY INSTILLED WITH DIESEL EXHAUST PARTICULATES AND ANTIGEN [J].

FUJIMAKI, H ;

NOHARA, O ;

ICHINOSE, T ;

WATANABE, N ;

SAITO, S .

TOXICOLOGY, 1994, 92 (1-3) :261-268

[9] INTRANASAL INSTILLATION OF DIESEL EXHAUST PARTICULATES AND ANTIGEN IN MICE MODULATED CYTOKINE PRODUCTIONS IN CERVICAL LYMPH-NODE CELLS [J].

FUJIMAKI, H ;

SANEYOSHI, K ;

NOHARA, O ;

SHIRAISHI, F ;

IMAI, T .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 108 (03) :268-273

[10] Inhalation of diesel exhaust enhances antigen-specific IgE antibody production in mice [J].

Fujimaki, H ;

Saneyoshi, K ;

Shiraishi, F ;

Imai, T ;

Endo, T .

TOXICOLOGY, 1997, 116 (1-3) :227-233

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