Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides

被引：24

作者：

Arimondo, PB

Moreau, P

Boutorine, A

Bailly, C

Prudhomme, M

Sun, JS

Garestier, T

Hélène, C

机构：

[1] Museum Natl Hist Nat, INSERM U201, UMR 8646 CNRS, Biophys Lab, F-75231 Paris 05, France

[2] Univ Clermont Ferrand 2, Lab Chim Organ Biol, CNRS URA 485, F-63177 Clermont Ferrand, France

[3] IRCL, INSERM U524, Ctr Oscar Lambret, F-59045 Lille, France

[4] IRCL, Lab Pharmacol Antitumorale, Ctr Oscar Lambret, F-59045 Lille, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(00)00012-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Indolocarbazole and benzopyridoquinoxaline derivatives have been shown to have anti-tumor activity and to stimulate DNA topoisomerase I-mediated cleavage. Two indolocarbazole compounds (R-6 and R-95) and one benzopyridoquinoxaline derivative (BPQ(1256)) were covalently attached to the 3'-end of a 16mer triple helix-forming oligonucleotide (TFO). These conjugates bind to DNA with a higher affinity than the unsubstituted oligonucleotides. Furthermore, they induce topoisomerase I-mediated and tripler-directed DNA cleavage in a sequence-specific manner. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：777 / 784

页数：8

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