Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?

被引：19

作者：

Chini, EN

De Toledo, FGS

机构：

[1] Mayo Clin & Mayo Fdn, Dept Anesthesiol, Rochester, MN 55905 USA

[2] Univ Miami, Jackson Mem Med Ctr, Dept Internal Med, Miami, FL 33136 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2002年 / 282卷 / 06期

关键词：

calcium; endoplasmic reticulum; fertilization; sea urchin eggs; cyclic adenosine 5 '-diphosphate-ribose;

D O I：

10.1152/ajpcell.00475.2001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question.

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页码：C1191 / C1198

页数：8

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