HIV type 1 RNA level as a clinical indicator of renal pathology in HIV-infected patients

被引：52

作者：

Estrella, Michelle

Fine, Derek M.

Gallant, Joel E.

Rahman, M. Hafizur

Nagajothi, Nagapradeep

Racusen, Lorraine C.

Scheel, Paul J.

Atta, Mohamed G.

机构：

[1] Johns Hopkins Univ, Div Nephrol, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Sch Med, Div Infect Dis, Baltimore, MD USA

[3] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA

[4] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

[5] Rosalind Franklin Univ Med & Sci, Dept Med, N Chicago, IL USA

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 03期

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; HIV-1-ASSOCIATED NEPHROPATHY; PROTEASE INHIBITORS; INSULIN-RESISTANCE; DIABETES-MELLITUS; LARGE COHORT; HYPERTENSION; PREVALENCE;

D O I：

10.1086/505497

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine the value of human immunodeficiency virus type 1 (HIV-1) RNA level in distinguishing HIV-associated nephropathy from non-HIV-associated nephropathy renal pathological conditions, we retrospectively compared renal histopathological findings for 86 HIV-infected patients according to HIV-1 RNA levels. We found that HIV-associated nephropathy was unlikely among patients with HIV-1 RNA levels < 400 copies/mL. Hypertensive vascular disease surpassed HIV-associated nephropathy as the most common renal pathological finding among the entire cohort. HIV-1 RNA level did not correlate with renal survival.

引用

页码：377 / 380

页数：4

共 21 条

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