Synthesis of a novel class of cdc25A inhibitors from vitamin D3

被引：22

作者：

Dodo, K

Takahashi, M

Yamada, Y

Sugimoto, Y

Hashimoto, Y

Shirai, R

机构：

[1] Nara Inst Sci & Technol, Res & Educ Ctr Mat Sci, Nara 6300101, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[3] Taiho Pharmaceut Co Ltd, Hanno Res Ctr, Canc Res Lab, Hanno Shi, Saitama 3578527, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)00065-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide, The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 mu M) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：615 / 617

页数：3

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