The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow

被引：71

作者：

Ingram, W.

Lea, N. C.

Cervera, J.

Germing, U.

Fenaux, P.

Cassinat, B.

Kiladjian, J. J.

Varkonyi, J.

Antunovic, P.

Westwood, N. B.

Arno, M. J.

Mohamedali, A.

Gaken, J.

Kontou, T.

Czepulkowski, B. H.

Twine, N. A.

Tamaska, J.

Csomer, J.

Benedek, S.

Gattermann, N.

Zipperer, E.

Giagounidis, A.

Garcia-Casado, Z.

Sanz, G.

Mufti, G. J.

机构：

[1] Kings Coll Hosp London, Dept Haematol Med, London, England

[2] Kings Coll London, London WC2R 2LS, England

[3] Hosp Univ La Fe, Serv Hematol & Hemoterapia, Valencia, Spain

[4] Univ Dusseldorf, Dept Haematol Oncol & Clin Immunol, D-4000 Dusseldorf, Germany

[5] Hosp Avicenne, Dept Hematol, Bobigny, France

[6] Semmelweis Univ, Dept Internal Med 3, Budapest, Hungary

[7] Linkoping Univ Hosp, Dept Haematol, S-58185 Linkoping, Sweden

[8] Kings Coll London, Genom Ctr, Sch Biomed & Hlth Sci, London WC2R 2LS, England

[9] Semmelweis Univ, Natl Hlth Ctr, Budapest, Hungary

[10] Semmelweis Univ, Inst Pathol & Canc Res, Budapest, Hungary

[11] St Johannes Hosp, Dept Oncol & Clin Immunol, Duisburg, Germany

来源：

LEUKEMIA | 2006年 / 20卷 / 07期

关键词：

D O I：

10.1038/sj.leu.2404215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1319 / 1321

页数：5

共 8 条

[1] Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders [J].

Baxter, EJ ;

Scott, LM ;

Campbell, PJ ;

East, C ;

Fourouclas, N ;

Swanton, S ;

Vassiliou, GS ;

Bench, AJ ;

Boyd, EM ;

Curtin, N ;

Scott, MA ;

Erber, WN ;

Green, AR .

LANCET, 2005, 365 (9464) :1054-1061

[2] Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis [J].

James, C ;

Delhommeau, F ;

Marzac, C ;

Teyssandier, I ;

Le Couédic, JP ;

Giraudier, S ;

Roy, L ;

Saulnier, P ;

Lacroix, L ;

Maury, S ;

Tulliez, M ;

Vainchenker, W ;

Ugo, V ;

Casadevall, N .

LEUKEMIA, 2006, 20 (02) :350-353

[3] A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera [J].

James, C ;

Ugo, V ;

Le Couédic, JP ;

Staerk, J ;

Delhommeau, F ;

Lacout, C ;

Garçon, L ;

Raslova, H ;

Berger, R ;

Bennaceur-Griscelli, A ;

Villeval, JL ;

Constantinescu, SN ;

Casadevall, N ;

Vainchenker, W .

NATURE, 2005, 434 (7037) :1144-1148

[4] Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders [J].

Jones, AV ;

Kreil, S ;

Zoi, K ;

Waghorn, K ;

Curtis, C ;

Zhang, LY ;

Score, J ;

Seear, R ;

Chase, AJ ;

Grand, FH ;

White, H ;

Zoi, C ;

Loukopoulos, D ;

Terpos, E ;

Vervessou, EC ;

Schultheis, B ;

Emig, M ;

Ernst, T ;

Lengfelder, E ;

Hehlmann, R ;

Hochhaus, A ;

Oscier, D ;

Silver, RT ;

Reiter, A ;

Cross, NCP .

BLOOD, 2005, 106 (06) :2162-2168

[5] A gain-of-function mutation of JAK2 in myeloproliferative disorders [J].

Kralovics, R ;

Passamonti, F ;

Buser, AS ;

Teo, S ;

Tiedt, R ;

Passweg, JR ;

Tichelli, A ;

Cazzola, M ;

Skoda, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (17) :1779-1790

[6] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis [J].

Levine, RL ;

Wadleigh, M ;

Cools, J ;

Ebert, BL ;

Wernig, G ;

Huntly, BJP ;

Boggon, TJ ;

Wlodarska, L ;

Clark, JJ ;

Moore, S ;

Adelsperger, J ;

Koo, S ;

Lee, JC ;

Gabriel, S ;

Mercher, T ;

D'Andrea, A ;

Fröhling, S ;

Döhner, K ;

Marynen, P ;

Vandenberghe, P ;

Mesa, RA ;

Tefferi, A ;

Griffin, JD ;

Eck, MJ ;

Sellers, WR ;

Meyerson, M ;

Golub, TR ;

Lee, SJ ;

Gilliland, DG .

CANCER CELL, 2005, 7 (04) :387-397

[7] Efficacy of lenalidomide in myelodysplastic syndromes [J].

List, A ;

Kurtin, S ;

Roe, DJ ;

Buresh, A ;

Mahadevan, D ;

Fuchs, D ;

Rimsza, L ;

Heaton, R ;

Knight, R ;

Zeldis, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (06) :549-557

[8] The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes [J].

Steensma, DP ;

Dewald, GW ;

Lasho, TL ;

Powell, HL ;

McClure, RF ;

Levine, RL ;

Gilliland, DG ;

Tefferi, A .

BLOOD, 2005, 106 (04) :1207-1209

← 1 →