Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives

被引：58

作者：

Honda, T

Masuda, T

Yoshida, S

Arai, M

Kobayashi, Y

Yamashita, M

机构：

[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Biol Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00328-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substitution of 7-OH by small hydrophobic groups on zanamivir resulted in the retaining of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. These compounds were prepared by treatment of the corresponding 7-substituted sialic acids derived from 4-modified N-acetyl-D-mannosamine (ManNAc) using enzyme-catalyzed aldol condensation. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1921 / 1924

页数：4

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