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Congenital heart defects and maternal derangement of homocysteine metabolism

被引：112
作者：
Kapusta, L
Haagmans, MLM
Steegers, EAP
Cuypers, MHM
Blom, HJ
Eskes, TKAB
机构：
[1] Univ Nijmegen Hosp, Childrens Heart Ctr, Dept Pediat, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen Hosp, Dept Obstet & Gynecol, NL-6500 HB Nijmegen, Netherlands
来源：
JOURNAL OF PEDIATRICS | 1999年 / 135卷 / 06期
关键词：
D O I：
10.1016/S0022-3476(99)70102-2
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Methionine loading tests and folate, vitamin B-6, and vitamin B-12 analyses were performed in 27 mothers of children with congenital heart defects. Median fasting plasma homocysteine concentrations were significantly higher in the study group as compared with 56 control subjects (P =.0001). Maternal hyperhomocysteinemia may be a risk factor for congenital heart defects.
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收藏
页码：773 / 774
页数：2
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