Design of Resorbable Porous Tubular Copolyester Scaffolds for Use in Nerve Regeneration

被引：67

作者：

Plikk, Peter ^{[1
]}

Malberg, Sofia ^{[1
]}

Albertsson, Ann-Christine ^{[1
]}

机构：

[1] Royal Inst Technol, Dept Fibre & Polymer Technol, Sch Chem Sci & Engn, SE-10044 Stockholm, Sweden

来源：

BIOMACROMOLECULES | 2009年 / 10卷 / 05期

关键词：

L-LACTIDE; ALIPHATIC POLYESTERS; EPSILON-CAPROLACTONE; MOLECULAR-WEIGHT; CYCLIC DIMER; COPOLYMERS; 1,5-DIOXEPAN-2-ONE; POLYMERIZATION; GUIDE; TIN;

D O I：

10.1021/bm900093r

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copolymers of L,L-lactide (LLA), epsilon-caprolactone (CL), trimethylene carbonate (TMC), or 1,5-dioxepane-2-one (DXO) were used to design porous tubular scaffolds with various mechanical properties, porosities, and numbers of layers in the tube wall. The mechanical properties of the tubular scaffold types showed good suitability for nerve regeneration and other nonload-bearing tissue engineering applications and were easy to handle without damaging the porous structure. A low stannous 2-ethylhexanoate-to-monomer ratio of 1:10000 did not change the tensile properties of the copolymer tubes significantly compared to those of scaffolds made using a Sn(Oct)(2)-to-monomer ratio of 1:600. The adaptability of the immersion coating and porogen leaching technique was demonstrated by creating tubes with different designs. Tubes with different wall layers were created by varying the immersion solutions, and the ease of altering the porosity, pore shape, and pore size was exemplified by using sodium chloride alone or mixed with poly(ethylene glycol) as porogen.

引用

页码：1259 / 1264

页数：6

共 33 条

[1] SYNTHESIS AND CHARACTERIZATION OF POLY(1,5-DIOXEPAN-2-ONE-CO-L-LACTIC ACID) AND POLY(1,5-DIOXEPAN-2-ONE CO-D,L-LACTIC ACID) [J].