Paclitaxel and concurrent radiation for gastric cancer

被引:31
作者
Safran, H
Wanebo, HJ
Hesketh, PJ
Akerman, P
Ianitti, D
Cioffi, W
DiPetrillo, T
Wolf, B
Koness, J
McAnaw, R
Moore, T
Chen, MH
Radie-Keane, K
机构
[1] Brown Univ, Oncol Grp, Providence, RI USA
[2] St Elizabeths Med Ctr, Dept Med, Boston, MA USA
[3] St Elizabeths Med Ctr, Dept Radiat Oncol, Boston, MA USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2000年 / 46卷 / 04期
关键词
paclitaxel; radiotherapy; gastric cancer;
D O I
10.1016/S0360-3016(99)00436-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine the activity and toxicity of paclitaxel and concurrent radiation for gastric cancer. Methods and Materials: Twenty-seven patients were studied. Twenty-five had proximal gastric cancers, two had distal cancers. Eight had esophageal extension, 6 had celiac adenopathy, and 7 had retroperitoneal adenopathy. Patients received paclitaxel, 50 mg/m(2) by 3-hour intravenous (IV) infusion, weekly, on days 1, 8, 15, 22, and 29. Radiation was administered concurrently to a total dose of 45.0 Gy, in 1.80 Gy fractions, for 25 treatments. Patients who were medically or surgically inoperable received a sixth week of paclitaxel with a radiation boost to 50.4 Gy. Results: Esophagitis and gastritis were the most important toxicities, Grade 3 in four patients (15%), and Grade 4 in three patients (11%). Five patients (19%) had Grade 3 nausea. The overall response rate was 56%, including three patients (11%) with a complete response. The 2-year progression-free and overall survival rates were 29% and 31%, respectively. Conclusion: Concurrent paclitaxel and radiation demonstrates substantial local-regional activity in gastric cancer. Future investigations combining paclitaxel and radiation with other local-regional and systemic treatments are warranted. (C) 2000 Elsevier Science Inc.
引用
收藏
页码:889 / 894
页数:6
相关论文
共 23 条
[1]   ACTIVITY OF TAXOL IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA AND ADENOCARCINOMA OF THE ESOPHAGUS [J].
AJANI, JA ;
ILSON, DH ;
DAUGHERTY, K ;
PAZDUR, R ;
LYNCH, PM ;
KELSEN, DP .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (14) :1086-1091
[2]   PHASE-I TRIAL OF OUTPATIENT WEEKLY PACLITAXEL AND CONCURRENT RADIATION-THERAPY FOR ADVANCED NON-SMALL-CELL LUNG-CANCER [J].
CHOY, H ;
AKERLEY, W ;
SAFRAN, H ;
CLARK, J ;
REGE, V ;
PAPA, A ;
GLANTZ, M ;
PUTHAWALA, Y ;
SODERBERG, C ;
LEONE, L .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (12) :2682-2686
[3]   Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer [J].
Choy, H ;
Akerley, W ;
Safran, H ;
Graziano, S ;
Chung, C ;
Williams, T ;
Cole, B ;
Kennedy, T .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (10) :3316-3322
[4]  
CHOY H, 1993, CANCER, V71, P3774, DOI 10.1002/1097-0142(19930601)71:11<3774::AID-CNCR2820711147>3.0.CO
[5]  
2-0
[6]  
Deisseroth A B, 1995, Cancer J Sci Am, V1, P15
[7]  
Einzig AI, 1993, P AN M AM SOC CLIN, V12, P195
[8]   ADENOCARCINOMA OF THE STOMACH - AREAS OF FAILURE IN A REOPERATION SERIES (2ND OR SYMPTOMATIC LOOK) CLINICOPATHOLOGIC CORRELATION AND IMPLICATIONS FOR ADJUVANT THERAPY [J].
GUNDERSON, LL ;
SOSIN, H .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (01) :1-11
[9]   Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation [J].
Gupta, N ;
Hu, LJ ;
Deen, DF .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 37 (04) :885-895
[10]   Cancer statistics, 1998 [J].
Landis, SH ;
Murray, T ;
Bolden, S ;
Wingo, PA .
CA-A CANCER JOURNAL FOR CLINICIANS, 1998, 48 (01) :6-+